TPP-enzymes (C-C-coupling enzymes)

TPP-enzymes catalyze the formation / cleavage of C-C bonds between carbonyl compounds. The reaction is mediated by the bound cofactor Thiamine pyrophosphate (TPP), which gives this group of enzymes its name. TPP-enzymes provide a biocatalytic approach to access diversely substituted enantiopure 2-hydroxy-ketones. These compounds have shown a lot of potential in synthesis, and have become interesting reaction intermediates for the chemical and pharmaceutical industries.

The evocatal C-C-coupling Kit provides you with a simple and cost-effective way of choosing the best among evocatal's TPP-enzymes with defined C-C-coupling activity. You find seven TPP-enzymes plus cofactor in one set, together with a comprehensive manual - ready to use. More 

evozymes	EC	characteristics	catalog-no.	datasheet
C-C Coupling Kit	-	7 TPP-enzymes plus cofactor TPP	evo-1.4.100	PDF
TPP 101	4.1.1.1	Donor: Aliphatic aldehydes, 2-keto acids Acceptor: Aromatic aldehydes Stereoselectivity: (R)-selective	evo-1.4.101	PDF
TPP 102	4.1.1.1	Donor: Aliphatic aldehydes, 2-keto acids Acceptor: aromatic aldehydes Stereoselectivity: (S)-selective	evo-1.4.102	PDF
TPP 103	4.1.1.7	Donor: Aromatic aldehydes, 2-keto acids Acceptor: Acetaldehyde, aromatic aldehydes Stereoselectivity: Benzoins: (R)-selective 2-Hydroxy-1-Phenyl-1-Propanon: (S)-selective	evo-1.4.103	PDF
TPP 104	4.1.1.7	Donor: Aromatic aldehydes, 2-keto acids Acceptor: Aliphatic Aldehydes Stereoselectivity: (S)-selective	evo-1.4.104	PDF
TPP 106	4.1.2.38	Donor: Aliphatic, aromatic aldehydes Acceptor: Aliphatic, aromatic aldehydes Stereoselectivity: (R)-selective	evo-1.4.106	PDF
TPP 107	4.1.1.72	Donor: branched aliphatic aldehydes Acceptor: aliphatic, aromatic aldehydes Stereoselectivity: (R)-selective	evo-1.4.107	PDF
TPP 108	-	Donor: Pyruvate Acceptor: small, bulky ketones Stereoselectivity: (R)-selective	evo-1.4.108	PDF

# HPP: 2-Hydroxy-1-phenyl-1-propanone

All of the enzymes are available in standard commercial quantities (from mg-kg).

evocatal also provides an enzyme screening service

Just send us your compound. Our experts will check it for fit, not only with the TPP-enzymes contained in the C-C-coupling Kit, but also against many other enzyme variants and additional extensive enzyme libraries.

If you would like more information about how to order, or have a question about the delivery conditions, please give us a call at +49 211-1576095-0.